LC/MS Products

 

Mobile Phase Blends, OPTIMA® LC/MS Grade

Mobile Phase

Fisher Chemical OPTIMA LC/MS solvents have set the standard of excellence for consistent, reproducible performance in the mobile phase of LC/MS. 
Now, these same high purity solvents are pre-blended with OPTIMA LC/MS modifiers such as formic acid (FA) or trifluoroacetic acid (TFA) to provide ready-to-use aqueous and organic mobile phase blends for LC/MS and LC/UV applications.
In recent laboratory experiments, Fisher Chemical OPTIMA LC/MS solvent blends were shown to meet the stringent purity requirements of LC/MS by providing a consistent concentration of FA or TFA, a very low mass baseline (noise level), exceptionally low metal ion content, and very low LC/UV background. Moreover, the protease-free specifi cation of the aqueous blends is important for proteomics research since peptides/proteins could be degraded if the mobile phase solution is contaminated with protease.

Fisher Chemical OPTIMA LC/MS pre-blended solvents are manufactured in facilities with an ISO 9001:2008 certifi ed quality system to ensure optimum quality and product uniformity.

Catalog No. Product Name
LS118 Formic acid, Optima® LC/MS grade, 0.1% solution in water
LS119 Trifluoroacetic acid, Optima® LC/MS grade, 0.1% solution in water
LS120 Formic acid, Optima® LC/MS grade, 0.1% solution in acetonitrile
LS121 Trifluoroacetic acid, Optima® LC/MS grade, 0.1% solution in acetonitrile
LS122 Acetonitrile, 80%, 20% Water with 0.1% Formic acid, Optima™ LC/MS
CAS Size 1 Size 2 Size 3 Size 4
64-18-6 500ML 1LT 2.5LT 4LT
76-05-1 500ML 1LT 2.5LT 4LT
64-18-6 500ML 1LT 2.5LT 4LT
76-05-1 500ML 1LT 2.5LT 4LT
75-05-8 500ML      

 

 

 

 


 

Solvents, OPTIMA® LC/MS Grade

The joining of liquid chromatography (LC) with mass spectrometry (MS) has become an indispensable tool for various fields of research. The value of LC/MS derives from its ability to combine separation chemistry with selective mass ion detection. 
As instrumentation advances lead to ever-lower analyte detection limits, it is crucial for the chromatographer to consider the level of purity when selecting appropriate solvents for use in the LC/MS mobile phase. 

The Fisher Chemical product line offers superior high-purity solvents designed to meet the required purity level of advanced LC/MS systems.

Catalog No. Product Name
A955 Acetonitrile, Optima® LC/MS grade
A456 Methanol, Optima® LC/MS grade
W6 Water, Optima® LC/MS grade
A461 Isopropanol, Optima® LC/MS grade
CAS Size 1 Size 2 Size 3 Size 4
75-05-8 500ML 1LT 2.5LT 4LT
67-56-1 500ML 1LT 2.5LT 4LT
7732-18-5 500ML 1LT 2.5LT 4LT
67-63-0 500ML 1LT 2.5LT 4LT

 

 

 

 


 

Reagents, OPTIMA® LC/MS Grade

Trifluoroacetic Acid, OPTIMA LC/MS Grade

Fisher Chemical OPTIMA LC/MS Grade Trifl uoroacetic Acid is an ultrapure reagent used as an additive for the formulation of solvent blends for the mobile phase in LC/MS applications.
Trifluoroacetic Acid is often added to the mobile phase to enhance chromatographic separations. When reversed-phase chromatography is applied to protein and peptide analysis, TFA is frequently used as an ion-pairing reagent in mobile phases.
Although TFA is known to suppress MS ionization, use of a low concentration of TFA can enhance retention and improve peak shape of a product during the analytical separations. 
For preparing mobile phase blends, A116-50 Trifl uoracetic Acid can be used with OPTIMA LC/MS Solvents such as A955 Acetonitrile, W6 Water, and A456 Methanol.

New! Acetic Acid, Ammonium Acetate, and Ammonium Formate

Achieving the full analytical potential of LC/MS instruments requires the use of highly purified solvents and ionic additives. Fisher Chemical OPTIMA LC/MS Ammonium Formate, Ammonium Acetate, and Acetic Acid are ultrapure reagents used to modify the LC/MS mobile phase in order to improve chromatographic peak shape and provide stable analyte signals in the MS detector.

Ammonium acetate and ammonium formate are volatile salts often used for improving ionization under neutral conditions in either the positive or negative ESI-MS mode.  Acetic acid is commonly used for enhancing chromatography separation under acidic conditions.

For preparing mobile phase blends, A113-50 Acetic Acid, A114-50 Ammonium Acetate, and A115-50 Ammonium Formate can be added to Fisher Chemical OPTIMA LC/MS solvents such as A955
Acetonitrile, W6 Water, and A456 Methanol.

Catalog No. Product Name
A113 Acetic acid, Optima® LC/MS grade
A114 Ammonium acetate, Optima® LC/MS grade
A115 Ammonium formate, Optima® LC/MS grade
A117 Formic acid, 99.5+%, Optima® LC/MS grade
A116 Trifluoroacetic acid, Optima® LC/MS grade
CAS Size 1 Size 2 Size 3 Size 4 Size 5
64-19-7 1AMP 10AMP 50ML    
631-61-8 50GR        
540-69-2 50GR        
64-18-6 0.5ML 10AMP 1ML 2ML 50ML
76-05-1 0.5ML 10ML 1ML 2ML 50ML

 

 

 

 

 

 

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